Insights into immune tolerance from AIRE deficiency
نویسندگان
چکیده
منابع مشابه
Aire Gets Company for Immune Tolerance
A specialized subset of epithelial cells in the thymus "promiscuously" transcribes thousands of peripheral genes to ensure that developing T cells can test their antigen receptors for dangerous autoreactivity. New findings by Takaba et al. indicate that the transcription factor Fezf2 acts independently of Aire in thymic epithelial cells to generate "genetic noise" for immunological tolerance.
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ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 2017
ISSN: 0952-7915
DOI: 10.1016/j.coi.2017.10.003